Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid.
作者： Carme Pelegrí , Joaquim Duran-Vilaregut , Jaume del Valle , Natàlia Crespo-Biel , Isidre Ferrer
DOI: 10.1016/J.IJDEVNEU.2008.07.016
关键词:
摘要: This study was undertaken to investigate the potential role of cell cycle re-entry in an experimental model Huntington's disease and human brain samples. We found that after treatment rats with mitochondrial neurotoxin 3-nitropropionic acid, expression markers G1 phase measured by immunohistochemistry induced striatal region. Furthermore, we detected increase nuclear also cytoplasmatic E2F-1 expression, suggesting this protein could activate apoptotic cascade rat brain. Western blot analysis post-mortem samples from patients showed cyclin D1 comparison control These results indicate is activated may contribute neurodegenerative process.
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