Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

作者: Sarit Assouline , Biljana Culjkovic , Eftihia Cocolakis , Caroline Rousseau , Nathalie Beslu

DOI: 10.1182/BLOOD-2009-02-205153

关键词:

摘要: … including M4/M5 subtypes of acute myeloid leukemia (AML). The oncogenic potential of … /M5 AML patients with a physical mimic of the m 7 G cap, ribavirin. Among 11 evaluable patients …

参考文章(17)
Gideon Koren, Sandra Knowles, Elizabeth Phillips, Susan King, Ribavirin in the treatment of SARS: A new trick for an old drug? Canadian Medical Association Journal. ,vol. 168, pp. 1289- 1292 ,(2003)
Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent, Rebecca L. Lynch, David Monteith, Spring N. Weir, Phil Schwier, Andrew Capen, Robin L. Goode, Michele S. Dowless, Yuefeng Chen, Hong Zhang, Sean Sissons, Karen Cox, Ann M. McNulty, Stephen H. Parsons, Tao Wang, Lillian Sams, Sandaruwan Geeganage, Larry E. Douglass, Blake Lee Neubauer, Nicholas M. Dean, Kerry Blanchard, Jianyong Shou, Louis F. Stancato, Julia H. Carter, Eric G. Marcusson, Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity Journal of Clinical Investigation. ,vol. 117, pp. 2638- 2648 ,(2007) , 10.1172/JCI32044
Ke Dong, Rui Wang, Xi Wang, Fang Lin, Jian-Jun Shen, Ping Gao, Hui-Zhong Zhang, Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells. Breast Cancer Research and Treatment. ,vol. 113, pp. 443- 456 ,(2009) , 10.1007/S10549-008-9956-X
Biljana Culjkovic, Keith Tan, Slobodanka Orolicki, Abdellatif Amri, Sylvain Meloche, Katherine L.B. Borden, The eIF4E RNA regulon promotes the Akt signaling pathway Journal of Cell Biology. ,vol. 181, pp. 51- 63 ,(2008) , 10.1083/JCB.200707018
Ivan Topisirovic, Biljana Culjkovic, Natalie Cohen, Jacqueline M Perez, Lucy Skrabanek, Katherine LB Borden, The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. The EMBO Journal. ,vol. 22, pp. 689- 703 ,(2003) , 10.1093/EMBOJ/CDG069
A. Kentsis, I. Topisirovic, B. Culjkovic, L. Shao, K. L. B. Borden, Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 18105- 18110 ,(2004) , 10.1073/PNAS.0406927102
Natalie Cohen, Madhulika Sharma, Alex Kentsis, Jacqueline M Perez, Stephen Strudwick, Katherine LB Borden, PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. The EMBO Journal. ,vol. 20, pp. 4547- 4559 ,(2001) , 10.1093/EMBOJ/20.16.4547
Katherine L B Borden, Ivan Topisirovic, Nadeem Siddiqui, Vincent Leroux Lapointe, Matthias Trost, Pierre Thibault, Catherine Bangeranye, Serafin Piñol-Roma, Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export‐competent RNP The EMBO Journal. ,vol. 28, pp. 1087- 1098 ,(2009) , 10.1038/EMBOJ.2009.53
Keith Tan, Biljana Culjkovic, Abdellatif Amri, Katherine L.B. Borden, Ribavirin targets eIF4E dependent Akt survival signaling Biochemical and Biophysical Research Communications. ,vol. 375, pp. 341- 345 ,(2008) , 10.1016/J.BBRC.2008.07.163