West Nile Virus-Induced Neurologic Sequelae—Relationship to Neurodegenerative Cascades and Dementias

摘要: West Nile virus (WNV) emerged from Central Africa in the 1990s and is now endemic throughout much of world. Twenty years after its introduction USA, it becoming apparent that neurological impairments can persist for following infection. Here, we review epidemiological data support such long-term deficits discuss possible mechanisms drive these persistent manifestations. Focusing on recently discovered antimicrobial roles amyloid alpha-synuclein, connect WNV late pathology to overlapping features encountered neurodegenerative diseases as Alzheimer’s disease Parkinson’s disease. We also summarize new research microglial activation engulfment neural synapses seen recovered well diseases, how loss integrity blood-brain barrier (BBB) may exacerbate this process. Neuroinvasive viral infections be linked epidemiologically mechanistically neurodegeneration. This open doors therapeutic options hitherto untreatable infectious sequelae; additionally, shed light etiologies age-progressive dementias.