Simultaneous analyses of the neurochemical and behavioral effects of the norepinephrine reuptake inhibitor reboxetine in a rat model of antidepressant action.

摘要: Abstract Rationale. The forced swimming test (FST) is a rodent behavioral assay widely used to predict clinical efficacy of putative antidepressants. Few studies have examined the effects FST on neurotransmitter levels and how antidepressant drug treatment may alter behavior simultaneously during performance stressful task. Objectives. present study role norepinephrine in mediating active behaviors after with reboxetine, selective reuptake inhibitor. Methods. High-pressure liquid chromatography was analyze microdialysis samples collected from awake, freely moving rats before, exposure FST. Reboxetine (10 mg/kg) given three times over 24-h period prior swim. Behavioral responses, including immobility, climbing, were counted 5-min day 1 day 2. Results. first swim stress elicited 65% increase extracellular (NE). A second day 2 52% NE profile characterized by increased immobility reduction behaviors. subchronic course (three injections 24 h) reboxetine between two exposures resulted antidepressant-like activity, i.e., decreased climbing significantly greater (112%) observed group animals that received injections. Conclusions. Treatment schedule commonly potentiated noradrenergic response challenge concomitant alterations consistent activity.