Storage of red cell concentrates in CPD-A2 for 42 and 49 days.

作者: E Beutler , C West

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摘要: CPD-A2 is a modified CPD blood preservative with adenine, containing 1 1/2 times as much glucose CPD. Units (450 ml) of from 21 normal donors were collected in plastic bags and held at room temperature for 8 hr. An 80% red cell concentrate was prepared this stored 42 or 49 days 4 degrees C, the containers either standing lying position. Measurements consumption, ATP, 2,3-DPG plasma hemoglobin, pH, Na+, K+ performed on all samples. The size "fragile tail" osmotically fragile cells estimated 12 poststorage 24 hr viability their own 51Cr-tagged documented 19 volunteers. At least months after original donation, second unit eight to make possible intradonor comparison biochemical effects storage After but not storage, concentrates position had consumed more higher pH than did averaged 83.6%, units exceeding 70% viability. average 69.1%. Although that standing, difference statistically significant 5% level. hemoglobin level showed weak correlation cells. Red ATP levels correlated only days' storage. Concentrates manifested fully satisfactory days. results studies borderline. High values are observed both may limit usefulness prolonged periods time.

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