Asthma and atopy are associated with chromosome 17q21 markers in Chinese children

摘要: Background:  Single-nucleotide polymorphism (SNP)-based genome-wide association study revealed that markers on chromosome 17q21 were linked to childhood asthma but not atopy in Caucasians, with the strongest signal being detected for SNP rs7216389 ORMDL3 gene. Such was unknown Chinese. This delineated allele and genotype frequencies of 10 SNPs at 17q21, investigated relationship between these plasma IgE southern Chinese children. Methods:  Asthmatic children non-allergic controls recruited from pediatric clinics. Their total aeroallergen-specific concentrations measured by immunoassay. Ten region genotyped multiplex SNaPshot™, their associations traits analyzed using multivariate regression. Results:  315 patients 192 enrolled. The frequency C varied significantly 0.232 our controls, 0.389 Han 0.536 Caucasians. Asthma diagnosis associated rs11650680 five other including (P = 0.019–0.034), whereas only (P = 0.0004). Linear regression covariates be significant (P = 0.008–0.0002). Haplotypic found increased IgE, respective odds ratios 95% confidence intervals TTTCCGTT haplotype 0.21 0.09–0.52 (P = 0.0002) 0.41 0.18–0.90 (P = 0.025). Conclusion:  Childhood are Chinese, such may involve genes than this region.