Rotavirus vaccines and vaccination potential.

摘要: The development of a successful rotavirus vaccine is complex problem. Our review shows that many challenges remain, and priorities for future studies need to be established. For example, the evaluation administration with OPV or breast milk might receive less emphasis until made clear efficacy against all virus serotypes. Samples remaining from previous trials should analyzed determine epitope-specific serum coproantibody responses clarify why only some were successful. Detailed antigenic properties viruses circulating causing illness in vaccinated children also performed comparisons strains. In trials, sample collection include monitoring asymptomatic infections cellular immune analyzed. diversity serotype distribution must monitored before, during, after trial study population placebo recipients matched carefully recipients. Epidemiologic molecular expanded document, disprove, possibility animal human transmission, because, if this occurs, protection may more difficult those areas world where cohabitation animals occurs. We have an accurate assessment rate follows natural infections. Is it realistic try achieve 90% protective these enteric pathogens provide 60% 70% protection? Subunit vaccines considered part strategies, especially maternal antibody interferes take live vaccines. constraints on new are not likely come biology. challenge remains whether biology immunology can understood exploited permit effective vaccination. Recent advances developing small models facilitate understanding response(s) (Ward et al. 1990b; Conner 1993).