Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

摘要: Tumors and the immune system are intertwined in a competition where tilting fine balance between tumor-specific immunity tolerance can ultimately decide fate of host. Defensive suppressive immunological responses to cancer exquisitely sensitive metabolic features rapidly growing tumors, such as hypoxia, low nutrient availability, aberrant growth factor signaling. As result, clinical therapies impacting these properties change situ antitumor response by virtue disrupting tumor environment. To compensate for disruptions cellular metabolism, cells activate autophagy promote survival. On basis this notion, strategies designed block currently being tested several human trials. However, that impair metabolism must also take into account their effect on lymphocytes activated cancer. Given strong is positive prognostic overall patient survival, identifying ways essential processes while promoting those important robust critical importance. Herein, we review effects anti-cancer agents impact administered concurrently with inhibitors consider implications therapy.