Within-host dynamics and random duration of pathogen infection: Implications for between-host transmission.
作者： Heather M. Lindberg , Kurt A. McKean , T. Caraco , Ing-Nang Wang
DOI: 10.1016/J.JTBI.2018.01.030
关键词:
摘要: Abstract Taking an ecological perspective, this paper reports theoretical and empirical results concerning fatal bacterial infections of adult insects. Two models, each combining deterministic stochastic elements, characterize how the pathogen’s dynamics might govern infected host’s mortality rate. We analyze models in detail for exponential pathogen growth, apply them to observed insect when growth is unregulated. then allow bacteriophage generate fluctuations within-host density; we demonstrate that only one our matches host rates regulated by phage. generalize on hazard individual hosts random duration infectious period can combine with probabilistic transmission events affect between-host transmission.
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