Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats
作者： François Windels , Nicolas Bruet , Annie Poupard , Claude Feuerstein , Anne Bertrand
DOI: 10.1002/JNR.10577
关键词:
摘要: High-frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, mechanisms HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that induces, normal rats, a significant increase extracellular glutamate (Glu) globus pallidus (GP rats or GPe primates) and substantia nigra pars reticulata (SNr), whereas gamma-aminobutyric acid (GABA) was increased only SNr. Bradykinesia can improved by STN frequency-dependent manner, plateau being reached around 130 Hz. The aim present study determine whether neurochemical changes are also frequency dependent. Electrical applied at various frequencies (10, 60, 130, 350 Hz) rats. results show that, Glu, amplitude detected GP SNr is maximal Hz maintained No modifications GABA were observed whatever applied, whereas, SNr, from 60 Our provide new data implicating target structures deep-brain-stimulation mechanisms.
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