Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

摘要: Abstract Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited the first pyridyl derivatives. biological results revealed efficiency core that could not be replaced clear beneficial effect 3-bromophenylamino moiety in position 3 triazole both (compounds 2.6 4.6) on several tested. Moreover, our point out an antiangiogenic these compounds. Overall, 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual activity.