Evidence Based Medicine: Recommendations for Pharmacological Treatment of Osteoarthritis Patients
作者： Tonko Vlak , Simeon Grazio , Božidar Ćurković , Branko Kopjar
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摘要: Nesteroidni antireumatici (NSAR) lijek su izbora u lijecenju boli bolesnika s osteoartritisom (OA). Velik broj razlicitih NSAR dostupnih na tržistu otežava izbor pojedinoga. Cilj rada: Kriticki pregledati tri tipa podataka koji se odnose (rezultati istraživanja, klinicko iskustvo i troskovi), radi davanja preporuka kao pomoc pri odlucivanju o terapiji. Materijali metode: Pretražene Cochrane, Medline Embase baze za pregledne clanke kontrolirana randomizirana ispitivanja klinickoj djelotvornosti nuspojavama NSAR. Klinicko temelji stavovima lijecnika-klinicara koautora rada. Podaci troskovima prodaji hrvatsko tržiste. Rezultati: Svi NSAR, ukljucujuci COX-2 selektivne inhibitore, imaju slicnu djelotvornost kontroli OA boli. Stetni ucinak gornji dio probavnoga trakta najmanji je diklofenak ibuprofen, dok iako vjerojatno manji, nije potpuno utvrđen. Ostale nuspojave rijetko znacenje, a inhibitore jos nisu dovoljno istražene. Dugogodisnje povoljno postoji diklofenakom ibuprofenom. Najniži troskovi lijecenja diklofenak, selektivni inhibitori znatno skuplji od neselektivnih Zakljucak: Diklofenak, potom ibuprofen ostaju prvi farmakoloskog OA.
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