Camptothecin and cisplatin upregulate ABCG2 and MRP2 expression by activating the ATM/NF-κB pathway in lung cancer cells
作者： SHI ZHONG KE , XIAO YAN NI , YUE HUA ZHANG , YI NAN WANG , BIN WU
关键词:
摘要: Multidrug resistance (MDR) formation is an important problem in lung cancer chemotherapy. Our study showed that both camptothecin and cisplatin could not only induce ATM NF-κB activation but also upregulate expression of the MDR-related genes ABCG2, MRP2 NCI-H446 cells. Moreover, cisplatin-induced ABCG2 upregulation be impaired by inhibitors, indicating a relationship between ATM, MDR chemo-therapy. indicates may serve as potential molecular target for
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