Infralimbic cortex controls core body temperature in a histamine dependent manner.

摘要: An increase in body temperature accelerates biochemical reactions and behavioral physiological responses. A mechanism to actively would be beneficial during motivated behaviors. The prefrontal cortex is implicated organizing behavior; the infralimbic cortex, a subregion of medial has necessary connectivity serve role initiating such thermogenic at beginning appetitive phase further, this active behavior its disinhibition produces marked vegetative arousal increase, together with increases histamine levels. We wanted explore if was related histaminergic activation after pharmacological behavior. measured core motor activity response picrotoxin injection as well food-related behavior, evoked by enticing hungry rats food. Pretreatment H1 receptor antagonist pyrilamine decreased thermal enticement completely blunted enticement. Motor responses were also abolished inhibition muscimol. To assess dependent produced an sympathetic mediated or just consequence increased locomotor activity, we injected propranolol (i.p.), β adrenergic blocker, before into cortex. Propranolol reduced without affecting activity. Altogether, these results suggest that for inducing central histamine.