Reaction of alantolactone, an allergenic sesquiterpene lactone, with some amino acids. Resultant loss of immunologic reactivity.

摘要: A study of the reaction a hapten, alantolactone, with some amino acids is reported. Previously, we have reported than an α-methylene group attached to γ-lactone immunologic requisite alantolactone and other sesquiterpene lactones. Such known be capable undergoing "Michael-type addition" sulfhydryl cysteine. We confirm this finding report that can also undergo addition imidazole histidine e-amino lysine, but not guanido arginine, hydroxyl serine, or thio ether function methionine. selected these for further because their nucleophilic side chain. Samples undergone such no longer produce allergic eczematous contact dermatitis, as measured by patch test.