Candidacy of liver stage antigen-1 for Plasmodium falciparum vaccine development

H.M. Müller, I. Reckmann, M.R. Hollingdale, H. Bujard, K.J. Robson, A. Crisanti, Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes. The EMBO Journal. ,vol. 12, pp. 2881- 2889 ,(1993) , 10.1002/J.1460-2075.1993.TB05950.X

M. R. Hollingdale, P. Druilhe, E. D. Franke, S. L. Hoffman, Attacking the infected hepatocyte. Malaria vaccine development: a multi-immune response approach.. pp. 35- 75 ,(1996)

J D Zhu, A P Waters, A Appiah, T F McCutchan, A A Lal, M R Hollingdale, Stage-specific ribosomal RNA expression switches during sporozoite invasion of hepatocytes. Journal of Biological Chemistry. ,vol. 265, pp. 12740- 12744 ,(1990) , 10.1016/S0021-9258(19)38407-8

Denise L. Doolan, Stephen L. Hoffman, The Complexity of Protective Immunity Against Liver-Stage Malaria The Journal of Immunology. ,vol. 165, pp. 1453- 1462 ,(2000) , 10.4049/JIMMUNOL.165.3.1453

Robert A. Seder, Adrian V. S. Hill, Vaccines against intracellular infections requiring cellular immunity. Nature. ,vol. 406, pp. 793- 798 ,(2000) , 10.1038/35021239

B Gesser, K Matsushima, K Thestrup-Pedersen, T Jinquan, C G Larsen, Human IL-10 is a chemoattractant for CD8+ T lymphocytes and an inhibitor of IL-8-induced CD4+ T lymphocyte migration. Journal of Immunology. ,vol. 151, pp. 4545- 4551 ,(1993)

U Krzych, J A Lyon, T Jareed, W R Ballou, M R Hollingdale, D M Gordon, I Schneider, T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens. Journal of Immunology. ,vol. 155, pp. 4072- 4077 ,(1995)

Peter G. Kremsner, Martina Bongartz, Adrian J.F. Luty, Philipp Rezbach, Jean-Francois Faucher, Michael R. Hollingdale, Plasmodium falciparum liver-stage antigen-1 peptide-specific interferon-gamma responses are not suppressed during uncomplicated malaria in African children European Cytokine Network. ,vol. 12, pp. 647- 653 ,(2002)

Deirdre Herrington, Elizabeth Nardin, Magda Beier, Myron Levine, Joseph Cortese, Hubert Eddy, Genevieve Losonsky, Ruth S. Nussenzweig, David Clyde, Michael Hollingdale, Robert Edelman, Marcelo Sztein, Jonathan Davis, Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. American Journal of Tropical Medicine and Hygiene. ,vol. 45, pp. 539- 547 ,(1991) , 10.4269/AJTMH.1991.45.539

F. Migot-Nabias, D. Luckner, P. G. Kremsner, R. Schmidt-Ott, K. Herbich, S. Ulbert, P. Deloron, L. G. Lehman, P. Matousek, A. J. F. Luty, B. Greve, B. Dubois, B. Lell, D. Schmid, Parasite antigen-specific interleukin-10 and antibody reponses predict accelerated parasite clearance in Plasmodium falciparum malaria. European Cytokine Network. ,vol. 9, pp. 639- 646 ,(1999)