Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases.

摘要: Immune responses are essential for the clearance of pathogens and repair injured tissues; however, if these not properly controlled, autoimmune diseases can occur. Autoimmune (ADs) a family disorders characterized by body's immune response being directed against its own tissues, with consequent chronic inflammation tissue damage. Despite enormous efforts to identify new drug targets develop therapies prevent ameliorate AD symptoms, no definitive solutions available today. Additionally, while substantial progress has been made in development some ADs, most treatments only symptoms and, general, ADs still incurable. Hundreds genetic loci have identified associated genome-wide association studies. However, whole list molecular factors that contribute pathogenesis is unknown. Noncoding (nc)RNAs, such as microRNAs, circular (circ)RNAs, long noncoding (lnc)RNAs, regulate gene expression at different levels various diseases, including serve potential well biomarkers disease progression therapy. In this review, we will focus on roles regulation ncRNA four diseases-systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes mellitus.