Abnormal vasomotor function of the epicardial coronary arteries in children five to eight years after arterial switch operation: an angiographic and intracoronary Doppler flow wire study.

摘要: Objectives This study sought to test the vasoreactivity of translocated coronary arteries after arterial switch operation (ASO) using quantitative angiographic analysis and intracoronary Doppler flow wire velocimetry. Background Late artery events occur in 3% 8% patients ASO. Previous studies reserve have yielded disparate results. Methods Nineteen children previously underwent ASO (13 boys, age 5.4 ± 3.2 years, weight 22.3 10.6 kg), six control were enrolled study. Each patient assessment epicardial before administration nitroglycerin blood volume adenosine acetylcholine. The results compared between groups. Results Epicardial dilation response was significantly less group than (left anterior descending [LAD], 5.0 0.05% vs. 18.0 4.5%, p = 0.0009; right [RCA], 4.0 0.07% 32.7 12.7%, 0.006). Moreover, reduced with infusion acetylcholine (2.3 0.9 4.9 1.7, 0.0003) or (2.7 1.5 5 0.5, 0.002). Conclusions fail dilate normally ASO, calculated is consequently reduced.