Calcium Channels in Fc Receptor Signaling

摘要: The calcium ion (Ca2+) is the main common second messenger involved in signaling transduction subsequent to immunoreceptor activation. Its rapid intracellular elevation induces multiple cellular responses, such as secretion, proliferation, mobility, and gene transcription. Intracellular levels of Ca2+ need reach a specific threshold efficiently transduce signal activate transcription factors through recruitment Ca2+-binding molecules. However, since cannot be metabolized, its concentration tightly regulated avoid induction programmed cell death. This highly controlled regulation homeostasis has recently been clarified by uncovering new channels. these channels allows role Fc receptor pathways more precisely defined.