High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors.
作者： Sayed-Mohammad Hasheminasab , Mladen V Tzvetkov , Christian Schumann , Stefan Rüdiger , Stefan Boeck
DOI: 10.2217/PGS.15.97
关键词:
摘要: Aim: To identify genomic variants in the EGFR pathway and cytokines predisposing to skin toxicity from inhibitors. Patients & methods: In 126 patients with cancer inhibitor therapy was quantified inflammatory genes were analyzed by deep sequencing. Results: We found 1437 SNPs 382-kb target region. Three intron 1 exclusively without rash. Another 23 SNP associated rash, overall survival IL8 plasma concentrations. Moreover, carriers of PIK3R1 326I variant predisposed rash better survival. Conclusion: Comprehensive pathway-based resequencing revealed some new but only moderately strong predictors toxicity.
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