Hepatitis B virus infection.
作者： Yun-Fan Liaw , Chia-Ming Chu , None
DOI: 10.1016/S0140-6736(09)60207-5
关键词:
摘要: Since the introduction of hepatitis B vaccine and other preventive measures, worldwide prevalence infection has fallen. However, chronic remains a challenging global health problem, with more than 350 million people chronically infected at risk hepatic decompensation, cirrhosis, hepatocellular carcinoma. An improved understanding virology, immunology, natural course infection, identified virus replication as key driver immune-mediated liver injury disease progression. The approval potent oral antiviral agents revolutionised treatment since 1998. Conventional pegylated interferon alfa nucleoside nucleotide analogues are widely authorised treatments, monotherapy these drugs greatly suppresses replication, reduces activity, halts is rarely eliminated, drug resistance major drawback during long term therapy. development new strategies needed to improve outcomes.
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