Mode of HCV infection examined by polymorphism of hypervariable region-1 in cases of acute hepatitis C after accidental exposure to blood-borne pathogens.

摘要: Acute hepatitis C is known to respond better interferon therapy than chronic C. The reason for this difference remains unclear. present study was undertaken examine HCV quasispecies in blood from patients with acute caused by accidental exposure blood-borne pathogens and the source patients. Three who developed (recipient patients; R-Pt.) two served as a of infection (source S-Pt.) were subjects study. number genetic diversity hypervariable region-1 (HVR-1) examined on basis fluorescence single-strand conformation polymorphism sequence analysis (FSSA). On day accident, 13 36 S-Pt.1 6 20 S-Pt.3, respectively. At time diagnosis hepatitis, nucleotide 2 R-Pt.1, 0 R-Pt.2, 4 R-Pt.3, Immediately before start treatment, 3 R-Pt.3., In three R-Pts, resulted eradication HCV. These findings indicate that early stage infection, only portion transmitted S-Pts R-Pts can proliferate. low appears be one reasons why responds well therapy.