Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair.

摘要: Diabetes is one of the most prevalent metabolic disorders and estimated to affect 400 million 4.4% population worldwide in next 20 year. In diabetes, risk develop vascular diseases two-to four-fold increased. Ischemic tissue injury, such as refractory wounds critical ischemic limb (CLI) are major complications diabetic patients where oxygen supplement insufficient due impaired angiogenesis/neovascularization. spite intensive studies, underlying mechanisms diabetes-impaired injury remain incompletely understood. Hydrogen sulfide (H2S) has been considered a third gasotransmitter regulating angiogenesis under physiological conditions. Here, H2S-impaired repair diabetes discussed. We will primarily focuses on signaling pathways H2S controlling endothelial function/biology, animal models. summarized that plays an important role maintaining function/biology angiogenic property diabetes. demonstrated exogenous may be theraputic agent for dysfunction