Physical Activity and Gynecologic Cancer Prevention

摘要: This chapter reviews the findings from epidemiologic studies of associations physical activity with gynecologic cancers, including those endometrium, ovaries, and cervix, biologic mechanisms mediating associations. The evidence to date suggests that probably protects against endometrial cancer, a risk reduction about 20–30% for highest levels compared lowest levels, light moderate housework, gardening, or walking transportation may reduce risk. role in ovarian cancer development remains uncertain, as these have been inconsistent half suggesting modestly decreases no association. A recent meta-analysis examining recreational estimated 20% reduced most active versus least women. There is mounting sedentary behaviors such sitting time increase cancers. Overall, there insufficient draw conclusion on possible cervical although modest influence through effects sex steroid hormones immune function. provides strong support protective cancers hormonal etiology. more established are supported by experimental data involve endogenous hormone insulin-mediated pathways, maintenance energy balance.