The Increased Skeletal Muscle Protein Turnover of the Streptozotozin Diabetic Rat Is Associated with High Concentrations of Branched-Chain Amino Acids

摘要: Experimental streptozotocin-induced diabetes resulted in important changes body weight which were associated with abnormalities water and food intake. In addition, diabetic rats showed a clear muscle atrophy involving decrease both skeletal size protein content. This was accompanied by marked loss of total carcass nitrogen. These related to alterations turnover muscle. Thus, the animals fractional rates synthesis (decreased 37%) degradation (increased 140%). The increased observed concentration circulating amino acids. Interestingly, did not show either liver or kidney rates, spite having increase (over 50%) mass. although acid affected state, chemically induced elevations branched-chain acids (leucine, isoleucine, valine) blood Similarly, decreases concentrations glutamate+glutamine, alanine, glycine, proline, serine, threonine also observed. observations reinforce idea association between wasting, turnover, previously proposed our group.