Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis.

摘要: Importance: While “omics” studies have advanced our understanding of inflammatory skin diseases, metabolomics is mostly an unexplored field in dermatology. Objective: We sought to elucidate the pathogenesis psoriatic diseases by determining differences metabolomic profiles among psoriasis patients with or without arthritis and healthy controls. Design: employed a global approach compare circulating metabolites from psoriasis, arthritis, controls. Setting: Study participants were recruited general community Psoriasis Clinic at University California Davis United States. Participants: examined using blood serum samples 30 age gender matched into three groups: 10 control participants. Main outcome(s) measures(s): Metabolite levels measured calculating mean peak intensities gas chromatography time-of-flight mass spectrometry. Results: Multivariate analyses revealed altered study population. Compared patients, had higher level alpha ketoglutaric acid (Pso: 288 ± 88; Control: 209 69; p=0.03), lower asparagine 5460 980; 7260 2100; p=0.02), glutamine 86000 20000; 111000 27000; p=0.02). increased glucuronic (Pso + PsA: 638 250; 347 61; p=0.001). alone, both decreased 186 80; Pso: p=0.02) lignoceric 442 280; 214 64; p=0.02). Conclusions relevance: The metabolite help they may provide insights for therapeutic development.