Prognostic Significance of Neuroadrenergic Dysfunction for Cardiovascular Events in Patients With Acute Myocardial Infarction.
作者： Masatoshi Minamisawa , Atsushi Izawa , Hirohiko Motoki , Yuichiro Kashima , Hirofumi Hioki
关键词:
摘要: BACKGROUND The dysregulation of systemic blood pressure (BP) variation or cardiac neuroadrenergic dysfunction is associated with adverse cardiovascular events. We aimed to clarify the prognostic significance for events in patients acute myocardial infarction (AMI). METHODS AND RESULTS enrolled 63 AMI (mean age, 67±12 years) underwent ambulatory BP monitoring (ABPM) and iodine-(123)metaiodobenzylguanidine (MIBG) imaging within 4 weeks after onset. analyzed circadian pattern heart-to-mediastinum (H/M) MIBG uptake ratio. All were followed 2 years. study endpoint was a composite major events, including all-cause death, MI, coronary revascularization except MI culprit lesion, stroke. Patients non-dipper (n=29) an H/M ratio <1.96 (n=28) had worse prognosis than those either dipper (n=34) ≥1.96 (n=35; log-rank, P=0.013 0.010, respectively). both (n=12) significantly did other (P=0.0020). CONCLUSIONS Dysregulation following AMI. Examining ABPM may potentially improve risk stratification these patients.
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