Compartmentalization of the foregut tube: developmental origins of the trachea and esophagus
作者： Sarah R. Fausett , John Klingensmith
DOI: 10.1002/WDEV.12
关键词:
摘要: The mammalian trachea and esophagus share a common embryonic origin. They arise by compartmentalization of single foregut tube, composed endoderm (FGE) surrounding mesenchyme, around midgestation. Aberrant is thought to lead relatively human birth defects, such as esophageal atresia (EA) tracheoesophageal fistula (EA/TEF), which can prevent or disrupt newborn infant's ability feed breathe. Despite its relevance health, morphogenesis the anterior still poorly understood. In this article, we provide comprehensive review formation from precursor, including origin FGE, current models for morphogenesis, relevant insights rodent models, emerging picture mechanisms underlying normal abnormal compartmentalization. Recent research suggests that number intercellular signaling pathways several intracellular effectors are essential correct esophagus. Different types defects in either ventral dorsal tissues models. This implies EA/TEF humans may also multiple mechanisms. Although our understanding growing rapidly, it incomplete. Future should focus on synthesizing detailed information gleaned both patients further enigmatic process. WIREs Dev Biol 2012, 1:184–202. doi: 10.1002/wdev.12 For resources related please visit website.
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