The impact of the circadian timing system on cardiovascular and metabolic function

摘要: Epidemiological studies show that adverse cardiovascular events peak in the morning (i.e., between 6 AM and noon) shift work is associated with disease, obesity, diabetes. The endogenous circadian timing system modulates certain risk markers to be highest (e.g., cortisol, nonlinear dynamic heart rate control, platelet activation) or respond most unfavorably stressors such as exercise epinephrine, norepinephrine, vagal cardiac modulation) at an internal body time corresponding of day when likely occur. This indicates its interaction external physical activity) could contribute events. Moreover, misalignment simulated night have effects on metabolic function. suggests behavioral cycle workers contributes population's increased for cardiometabolic disease.