fMRI evidence of neural abnormalities in the subcortical face processing system in ASD.

摘要: Recent evidence suggests that a rapid, automatic face detection system is supported by subcortical structures including the amygdala, pulvinar, and superior colliculus. Early-emerging abnormalities in these may be related to reduced social orienting children with autism, subsequently, aberrant development of cortical circuits involved processing. Our objective was determine whether functional processing are present adults autism spectrum disorders (ASD) during supraliminal fearful Participants included twenty-eight individuals ASD 25 controls group-matched on age, IQ, behavioral performance. The group met diagnostic criteria ADI-R, ADOS-G, DSM-IV. Both control groups showed significant activation bilateral fusiform gyri. exhibited additional responses right colliculi. In direct comparison, significantly greater left gyrus, No brain region compared controls. Thus, basic rapid identification mechanisms appear ASD. However, failed engage regions emotional processing, suggesting core mechanism for impaired socioemotional Neural this contribute early-emerging deficits attention, putative precursors cognition specialization.