Aryl and heteroaryl compounds and methods to modulate coagulation
作者： Robert Rothlein , Devi Reddy Gohimmukkula , Adnan M. M. Mjalli , Christopher Behme , Daniel Peter Christen
DOI:
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摘要: This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the and use in treating human or animal disorders. The compounds are useful as antagonists, more preferably, partial antagonist factor IX thus, may be used to inhibit intrinsic pathway blood coagulation. a variety applications including management, treatment and/or control diseases caused part by clotting utilizing IX. Such disease states include stroke, myocardial infarction, aneurysm surgery, deep vein thrombosis associated with surgical procedures, long periods confinement, acquired inherited pro-coagulant states.
lens.org参考文章(148)
Thomas E. Lane, Methods for treating rheumatoid arthritis ,(2004)
Thomas Gadek, James Marsters, David Oare, Robert McDowell, Mark Stanley, Kenneth Weese, Mark Reynolds, Daniel Burdick, Antagonists for treatment of CD/11CD18 adhesion receptor mediated disorders ,(2003)
Philip J. Fay, Paul S. Bajaj, Factor ixa: factor viiia interaction and methods therefor ,(2002)
Blaise Magloire N'zemba, Jocelyn Yelle, Guy Sevigny, Gilles Sauve, Aromatic derivatives with hiv integrase inhibitory properties Official Gazette of the United States Patent and Trademark Office Patents. ,(2001)
Armin Walser, Pavel Safar, Method of treating hyperresorptive bone disorders ,(2002)
Stephen E. deLaszlo, William K. Hagmann, Para-aminomethylaryl carboxamide derivatives ,(1998)
Terance Hart, Tony Johnson, Martin Quibell, Auto-deconvoluting combinatorial libraries ,(1997)
George Doherty, Richard A. Mumford, Linda L. Chang, Linus S. Lin, Shrenik K. Shah, William K. Hagmann, N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors ,(2002)
Edmund Schaut, Gerd Grass, Ruediger Weiss, Bernd Roos, Jens Wolber, Method for determining a hot-start situation in an internal combustion engine ,(2001)
Jose Halperin, Carlo Brugnara, Heather N. Taft, John J. Clifford, Minghua Sun, Mark Froimowitz, Richard John Lombardy, Adel M. Moussa, Yesh P. Sachdeva, Ying-Duo Gao, Eugene W. Kelleher, Falguni M. Kher, Reem M. Haidar, Emile M. Bellot, Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease ,(2001)