Investigation of a possible interaction between ciprofloxacin and cyclosporine in renal transplant patients

摘要: Background. Bacterial infection is a common complication during the first few months after renal transplantation. Ciprofloxacin, fluoroquinolone broad-spectrum antibiotic, used frequently in treating infections early posttransplant period. Evidence from vitro studies has suggested that ciprofloxacin can antagonize cyclosporine (CsA)-dependent inhibition of interleukin-2 production. Such an effect transplant patients could immunosuppressive activity CsA and lead to rejection graft. Methods. To investigate possibility pharmacodynamic interaction between CsA, we conducted case-control study 42 who had received kidney were prescribed 1-6 transplantation their matched controls (two per case) did not receive Results. There was twofold greater incidence (P=0.008) use at 1-3 (65%) than observed 4-7 (35%) The proportion cases experiencing least one episode biopsy-proven (45%) significantly (P=0.004) (19%). Furthermore, there marked increase (P<0.001) temporally associated with among (29%) compared experienced by (2%). Conclusions. increases rates may be clinical importance therefore warrants further investigation.