Mast cell membrane antigens and Fc receptors in anaphylaxis. II. Functionally distinct receptors for IgG and for IgE on mouse mast cells.

摘要: Abstract The present work was aimed at analyzing the functional relationships between mouse mast cell receptors for IgG and IgE antibodies. It based on a study of inhibition IgG1-and IgE-induced passive degranulation produced by various immunoglobulin preparations capable interfering with Fc receptors. Rat myeloma IgE, high-affinity ligand receptors, used to search possible participation in IgG1-dependent degranulation. Mouse IgG, which inhibited only weakly IgG1-mediated reactions, had no chance compete successfully antibodies, but aggregated HGG found behave as This enabled us IgE-dependent results show that rat specifically IgG1-induced respectively, failed inhibit reactions not requiring free conclusion are functionally independent cells, both expressed same cells.