Coronary heart disease and iron status: meta-analyses of prospective studies.

摘要: Background —Studies of iron status and coronary heart disease (CHD) have yielded conflicting results. In a systematic review (“meta-analysis”), we quantitatively assessed epidemiological associations reported in prospective studies. Methods Results were identified by computer-assisted searches the published literature, scanning relevant reference lists, hand searching journals, discussions with authors. The following was abstracted: size type cohort, mean age, duration follow-up, assay methods, degree adjustment for confounders, relationship CHD risk to baseline Twelve studies identified, involving total 7800 cases, several reporting on >1 marker status. For serum ferritin, 570 cases 5 studies, comparison individuals values ≥200 versus <200 μg/L combined ratio 1.0 (95% CI, 0.8 1.3). transferrin saturation, 6194 top third those bottom measurements 0.9 0.7 1.1). Comparisons thirds also nonsignificant ratios analyses iron-binding capacity (combined ratio, 1.0; 95% 1.5), (0.8; 1.0), dietary 1.1). Conclusions —Published do not provide good evidence support existence strong between CHD.