Calcium dependency of the binding and mitogenicity of phytohemagglutinin. Differentiation between calcium-dependent and independent binding events.

摘要: Abstract The same amount of phytohemagglutinin binds to lymphocytes at 37 °C and 0 °C. binding is inhibited by calcium chelators °C, but not during the very first minutes contact between lectin cells. N-Acetylgalactosamine in high concentrations inhibits both temperatures. abortive sense that it does result subsequent DNA synthesis. These findings indicate phytohemagglutin (PHA) glycoprotein receptor on cell surface itself activate immediate transducer mitogenic signal. has be accompanied some change which involves occurs rapidly, cannot take place give a proper anchorage PHA