Process for preparing a human thrombin concentrate intended for therapeutic use

摘要: Process for preparing a human thrombin concentrate from the PPSB fraction of plasma that does not involve any addition factors animal origin to induce activation prothrombin produce thrombin, and which includes viral inactivation step using solvent-detergent purification by cation exchange chromatography. The choice protective medium ensures high specific activity final product. obtained this process is intended therapeutic use, either alone, serve as local hemostatic agent, or in combination with fibrinogen form biological glue.