Neural correlates of response reversal: considering acquisition.

摘要: Previous work on response reversal has typically used a single pair of stimuli that serially reverse. This conflation acquisition and processes prevented an examination the functional role neural systems implicated in during despite relevance such data evaluating accounts reversal. In current study, participants encountered 16 independent reversing stimulus pairs context probabilistic paradigm. Functional regions interest identified as involved through contrast previous literature (punished errors made phase versus rewarded correct responses), were interrogated across conditions. Consistent with suggestions middle frontal cortex codes reward, this region showed significantly greater responses to rather than punished trials irrespective accuracy or learning (acquisition reversal). suggestion coding expectation reinforcement is acquired via input from amygdala, we observed significant positive connectivity between activity within amygdala rostral anterior cingulate highly proximal frontal/mesial prefrontal cortex. contrast, inferior cortex, caudate responses. These three also activation acquisition, positions suggesting represents punishment suppresses previously Moreover, analysis seed revealed among them. The implications these for recent impairments specific neuropsychiatric populations are discussed.