Does apolipoprotein E genotype influence cognition in middle-aged individuals?
作者： Gerardo Salvato
DOI: 10.1097/WCO.0000000000000262
关键词:
摘要: PURPOSE OF REVIEW The apolipoprotein e4 (APOE e4) allele has been recognized as a risk factor for the late-onset Alzheimer's disease. It may modulate cognitive performance in nondemented younger and older carriers. Does APOE genotype affect cognition mid-aged population well? In this review, summary of current evidence concerning effect on middle-aged individuals will be presented. RECENT FINDINGS Recent findings did not provide clear signature mid-life. A positive, negative, null functions observed, especially memory performance. SUMMARY discrepancy results because several limitations. Future studies should focused narrower participants' age range wider level education range. Moreover, explored by means more sensitive tasks. Finally, interaction between additional factors other allelic variants taken into account to fully understand brain cognition.
sci-hub.se 参考文章(29)
Francisco Lopera-Restrepo, Óscar Sierra-Fitzgerald, Guillermo Barreto, Ausencia de efecto cognitivo APOE en personas sanas de edad mediana Acta Neurológica Colombiana. ,vol. 29, pp. 163- 172 ,(2013)
Natalie L Marchant, Sarah L King, Naji Tabet, Jennifer M Rusted, Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers. Neuropsychopharmacology. ,vol. 35, pp. 1090- 1096 ,(2010) , 10.1038/NPP.2009.214
Yaakov Stern, Influence of Education and Occupation on the Incidence of Alzheimer's Disease JAMA. ,vol. 271, pp. 1004- 1010 ,(1994) , 10.1001/JAMA.1994.03510370056032
J.M. Rusted, S.L. Evans, S.L. King, N. Dowell, N. Tabet, P.S. Tofts, APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures. NeuroImage. ,vol. 65, pp. 364- 373 ,(2013) , 10.1016/J.NEUROIMAGE.2012.10.010
Nick M. Wisdom, Jennifer L. Callahan, Keith A. Hawkins, The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis Neurobiology of Aging. ,vol. 32, pp. 63- 74 ,(2011) , 10.1016/J.NEUROBIOLAGING.2009.02.003
P. M. Greenwood, Chantal Lambert, Trey Sunderland, Raja Parasuraman, Effects of Apolipoprotein E Genotype on Spatial Attention, Working Memory, and Their Interaction in Healthy, Middle-Aged Adults: Results From the National Institute of Mental Health’s BIOCARD Study Neuropsychology (journal). ,vol. 19, pp. 199- 211 ,(2005) , 10.1037/0894-4105.19.2.199
Eric M. Reiman, Richard J. Caselli, Lang S. Yun, Kewei Chen, Daniel Bandy, Satoshi Minoshima, Stephen N. Thibodeau, David Osborne, Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. The New England Journal of Medicine. ,vol. 334, pp. 752- 758 ,(1996) , 10.1056/NEJM199603213341202
Matthew S. Panizzon, Richard Hauger, Hong Xian, Eero Vuoksimaa, Kelly M. Spoon, Sally P. Mendoza, Kristen C. Jacobson, Terrie Vasilopoulos, Brinda K. Rana, Ruth McKenzie, Jeanne M. McCaffery, Michael J. Lyons, William S. Kremen, Carol E. Franz, Interaction of APOE genotype and testosterone on episodic memory in middle-aged men. Neurobiology of Aging. ,vol. 35, pp. 1778- ,(2014) , 10.1016/J.NEUROBIOLAGING.2013.12.025
Janine D. Flory, Stephen B. Manuck, Robert E. Ferrell, Christopher M. Ryan, Matthew F. Muldoon, Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults. American Journal of Medical Genetics. ,vol. 96, pp. 707- 711 ,(2000) , 10.1002/1096-8628(20001204)96:6<707::AID-AJMG1>3.0.CO;2-V
H. Braak, E. Braak, Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica. ,vol. 82, pp. 239- 259 ,(1991) , 10.1007/BF00308809