Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
作者： Vittorio Locatelli , Vittorio E. Bianchi
DOI: 10.1155/2014/235060
关键词:
摘要: Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal during puberty bone health throughout life. GH increases tissue formation by acting directly indirectly on target cells; IGF-1 is a critical mediator of growth. Clinical studies reporting the use osteoporosis fracture healing outlined. Methods. A Pubmed search revealed 39 clinical effects administration metabolism osteopenic osteoporotic human subjects operated patients with normal secretion. Eighteen considered effect treatment, fourteen reported administration, seven related to GH/IGF-1 healing. Results. Both significantly increased resorption most studies. hip or tibial fractures resulted healing, rapid improvements. Some conflicting results were evidenced. Conclusions. therapy has significant anabolic effect. for treatment may greatly improve outcome. interacts sex steroids process. resistance process considered.
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