Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease

摘要: Abstract Space radiation is comprised of highly charged ions (HZE particles) and protons that are able to pass through matter cause radiation-induced injury, including neuronal damage degeneration, glial activation, oxidative stress. Previous work demonstrated a worsening Alzheimer's disease pathology in the APP/PS1 transgenic mouse model, however effects space on tau have not been studied. To determine whether altered by HZE particle or proton irradiation, we exposed 3xTg mice, which acquire both amyloid plaque with age, iron, silicon, solar event (SPE) irradiation at 9 months age evaluated behavior brain 16 age. We found no differences performance fear conditioning novel object recognition tasks between groups mice sham, iron (10 100 cGy), silicon (200 though female had higher freezing responses than males. 200 cGy SPE irradiated fewer plaques sham-irradiated females but pathology. Overall, worse reduced neuroinflammatory gene expression response radiation. These findings uncover models following injury corroborate prior reports sex within model.