In vitro tests to assess toxic effects of airborne PM10 samples. Correlation with metals and chlorinated dioxins and furans
作者： Neus Roig , Jordi Sierra , Joaquim Rovira , Marta Schuhmacher , José L. Domingo
DOI: 10.1016/J.SCITOTENV.2012.11.022
关键词:
摘要: Inhalation is an important exposure pathway to airborne pollutants such as heavy metals, polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) particulate matter. Chronic those chemicals, which form part of complex environmental mixtures, may mean human health risks. In the present study, suitability different in vitro tests evaluate toxic effects air PM(10) investigated. addition, it also assessed how distinguish contribution chemical toxicity. Sixty-three samples were collected various areas Catalonia (Spain), levels ecotoxicity, cytotoxicity genotoxicity evaluated. Aqueous acidic extractions quartz fiber filters, where had been retained, performed. The photo-luminescent bacteria Vibrio fischeri (Microtox®) bioassay was performed assess ecotoxicity. Moreover, MTT Comet Assays, both using lung epithelial cells A549 target cells, applied samples, respectively. results show that Microtox® excellent screening test perform a first evaluation quality, presented significant correlation with contaminants, contrasting Assay. Although none exhibited genotoxicity, high found between this carcinogenic agents. Urban from traffic-impacted would be significantly more toxic. Finally, temperature identified key parameter, higher values ecotoxicity winter.
harvard.edu
sci-hub.se 参考文章(49)
Neus Roig, Martí Nadal, Jordi Sierra, Antoni Ginebreda, Marta Schuhmacher, José L. Domingo, Novel approach for assessing heavy metal pollution and ecotoxicological status of rivers by means of passive sampling methods Environment International. ,vol. 37, pp. 671- 677 ,(2011) , 10.1016/J.ENVINT.2011.01.007
Honglian Shi, Xianglin Shi, Ke Jian Liu, Oxidative mechanism of arsenic toxicity and carcinogenesis. Molecular and Cellular Biochemistry. ,vol. 255, pp. 67- 78 ,(2004) , 10.1023/B:MCBI.0000007262.26044.E8
Neus Roig, Jordi Sierra, Martí Nadal, Esther Martí, Pedro Navalón-Madrigal, Marta Schuhmacher, José L. Domingo, Relationship between pollutant content and ecotoxicity of sewage sludges from Spanish wastewater treatment plants Science of The Total Environment. ,vol. 425, pp. 99- 109 ,(2012) , 10.1016/J.SCITOTENV.2012.03.018
Brice M.R. Appenzeller, Aristidis M. Tsatsakis, Hair analysis for biomonitoring of environmental and occupational exposure to organic pollutants: State of the art, critical review and future needs Toxicology Letters. ,vol. 210, pp. 119- 140 ,(2012) , 10.1016/J.TOXLET.2011.10.021
Joaquim Rovira, Montse Mari, Martí Nadal, Marta Schuhmacher, José L. Domingo, Partial replacement of fossil fuel in a cement plant: risk assessment for the population living in the neighborhood. Science of The Total Environment. ,vol. 408, pp. 5372- 5380 ,(2010) , 10.1016/J.SCITOTENV.2010.07.060
J. H. Clemons, L. M. Allan, C. H. Marvin, Z. Wu, B. E. McCarry, D. W. Bryant, T. R. Zacharewski, Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM10 Air Particulate Material Using in Vitro Gene Expression Assays Environmental Science & Technology. ,vol. 32, pp. 1853- 1860 ,(1998) , 10.1021/ES971124N
Noemí Pérez, Jorge Pey, Michael Cusack, Cristina Reche, Xavier Querol, Andrés Alastuey, Mar Viana, Variability of Particle Number, Black Carbon, and PM10, PM2.5, and PM1 Levels and Speciation: Influence of Road Traffic Emissions on Urban Air Quality Aerosol Science and Technology. ,vol. 44, pp. 487- 499 ,(2010) , 10.1080/02786821003758286
Maurizio Gualtieri, Johan Øvrevik, Jørn A. Holme, M. Grazia Perrone, Ezio Bolzacchini, Per E. Schwarze, Marina Camatini, Differences in cytotoxicity versus pro-inflammatory potency of different PM fractions in human epithelial lung cells. Toxicology in Vitro. ,vol. 24, pp. 29- 39 ,(2010) , 10.1016/J.TIV.2009.09.013
Lolita Vilavert, Martí Nadal, Montse Mari, Marta Schuhmacher, José L. Domingo, Modification of an environmental surveillance program to monitor PCDD/Fs and metals around a municipal solid waste incinerator. Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering. ,vol. 44, pp. 1343- 1352 ,(2009) , 10.1080/10934520903213210
G. Toscano, I. Moret, A. Gambaro, C. Barbante, G. Capodaglio, Distribution and seasonal variability of trace elements in atmospheric particulate in the Venice Lagoon. Chemosphere. ,vol. 85, pp. 1518- 1524 ,(2011) , 10.1016/J.CHEMOSPHERE.2011.09.045