Dengue virus specific dual HLA binding T cell epitopes induce CD8+ T cell responses in seropositive individuals

摘要: Dengue virus infects an estimated 300 million people each year and even more are at risk of becoming infected as the continues to spread into new areas. Despite increase in viral prevalence, no anti-viral medications or vaccines approved for treating preventing infection. CD8+ T cell responses play a major role clearance. Therefore, effective that induce broad, multi-functional response with substantial cross-reactivity between all serotypes can have impacts on reducing infection rates related complications. Here, we took immunoproteomic approach identify novel MHC class I restricted epitopes presented by dengue cells, representing natural authentic targets response. Using this identified 4 MHC-I epitopes: 2 binding motif HLA-A24 molecules both HLA-A2 motifs. These peptides were able activate response...