Relationships Between Copper-Related Proteomes and Lifestyles in β Proteobacteria.

摘要: Copper is an essential transition metal whose redox properties are used for a variety of enzymatic oxido-reductions and in electron transfer chains. It also toxic to living beings, therefore its cellular concentration must be strictly controlled. We have performed silico analyses the predicted proteomes more than one hundred species β proteobacteria characterize their copper-related proteomes, including cuproproteins, i.e., proteins with active-site copper ions, chaperones, copper-homeostasis systems. Copper-related represent between 0 1.48% total proteobacteria. The numbers cuproproteins globally proportional proteome sizes all phylogenetic groups strongly linked aerobic respiration. In contrast, environmental bacteria considerably larger proportions systems other bacteria, irrespective sizes. Evolution toward commensalism, obligate, host-restricted pathogenesis or symbiosis reflected loss endosymbionts, defense chaperones disappeared, whereas residual cuproenzymes Lifestyle thus major determinant size composition proteome, it particularly involved homeostasis. Analyses number belonging Burkholderia, Bordetella, Neisseria genera indicates that commensals process shedding greater extents yet pathogens.