Sustained Release of Antibiotic From a Fibrin‐Gelatin‐Antibiotic Mixture
作者： Moon Suh Park , Yong Bok Kim
DOI: 10.1097/00005537-199710000-00016
关键词:
摘要: To improve the therapeutic effect of antibiotics in ear cavity postoperatively, a fibrin- and gelatin-based drug delivery system was designed vitro efficacy evaluated. Four kinds fibrin clot were made from ampicillin, gentamicin, ofloxacin, biologic assay performed using Bacillus subtilis. The fibrin-gelatin-gentamicin mixture demonstrated antibiotic activity for up to 120 hours against B Gentamicin found be released more slowly fibrin-gelatin than this experiment. These results suggest that device can clinically used limited field such as postoperative care infection.
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