Imported onchocerciasis in migrants and travelers.

摘要: PURPOSE OF REVIEW With increasing international travel and mass global population migration, clinicians in nonendemic countries must be familiar with imported neglected tropical diseases including onchocerciasis, which is commonly known as 'river blindness'. RECENT FINDINGS Imported onchocerciasis manifests differently travelers compared migrants from endemic areas likely underdiagnosed both groups. Recent clinical studies confirm that eosinophilia not a sensitive marker for Onchocerca volvulus, one-third of patients having normal eosinophil count. Novel diagnostics measuring antibodies to multiple recombinant O. volvulus antigens maintain high sensitivity while improving specificity conventional pan-filarial serologic testing. A 6-week course doxycycline has macrofilaricidal activity through Wolbachia depletion may useful addition standard serial ivermectin. SUMMARY characterizing distinct presentations enable better recognize onchocerciasis. Although novel have improved specificity, most remain restricted disease reference laboratories date there no cure. Prolonged treatment reduce the need ivermectin, though more potent short-course drugs are being developed.