The Experimental Model of the Autoimmune Glomerulonephritis Induced by the Chronic Graft versus Host Reaction

摘要: Graft-versus-host reaction (GVHR) is a cellular immune developed by transplanting mature T-lymphocytes to tissue incompatible recipients. As it has been stated R.E. Billingham in Harvey Lecture, there are three requirements for the development of GVHR: graft must contain immunologically competent cells; recipient be incapable rejecting transplanted express antigens that not present donor (Billingham, 1966, as cited Sun et al., 2007). There several situations which it’s possible: introduction lymphocytes newborn or adult immunocompromised recipients transfer parental F1 hybrids. A with normal system will usually reject cells from foreign donor. At time described and characterized two forms graft-versus-host reaction: acute chronic. The mechanisms chronic GVHR distinguished participating CD8+T-cells. If CD8+T-cells involved processes, primary stimulating phase (activation cell alloantigens) followed cytotoxic including generation effector – T (CTL), directed against alloantigens, ends destruction host tissues. In general, can called physiological "graft versus host" accomplished response allogeneic recipient. From this viewpoint an incomplete ("defective") does lead formation CD8+T-effector phase, should be, but «freezes» at stage lymphoproliferation. Such type may caused different situations: removal inactivation some inoculum subpopulations, suppression pharmacological agents early stages, lack stimulation through absence MHC class I incompatibility.