Application of Heteronuclear NMR Spectroscopy to Bioinorganic and Medicinal Chemistry
作者： Eirini Fotopoulou , Luca Ronconi
DOI: 10.1016/B978-0-12-409547-2.10947-3
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摘要: Nuclear magnetic resonance spectroscopy is among the major analytic techniques to study biologically relevant macromolecules, including metal-containing species, and speciate organic metal-based drugs. A number of readily observed I = 1/2 nuclei can be used on purpose (e.g., 1 H, 13 C, 15 N, 19 F, 31 P), but only a few metals fall into this category. Most are quadrupolar having low detection sensitivity giving rise broad lines. However, in some cases, heteronuclear and, particular, metal NMR studies provide insights biological activity range chemical species. The use ‘exotic nuclei’ reviewed here focusing its applications bioinorganic medicinal chemistry so as stimulate further advances research field.
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