Eudragit E as coating material for the pH-controlled drug release in the topical treatment of inflammatory bowel disease (IBD).
作者： Claudia S. Leopold , Dorothee Eikeler
DOI: 10.3109/10611869808997884
关键词:
摘要: AbstractDuring an attack of ulcerative colitis the colonic pH normally 6.4-7.0 drops to values 2.3–4.7. The objective this study was investigate acid-soluble polymer (Eudragit® E) as coating material for multiple units (mini tablets) with regard its ability allow drug release only under acidic conditions inflamed colon. Mini tablets (⊖ 3 mm) containing 20% (w/w) model dexamethasone or without mucoadhesive swelling agent carbomer 934 (neutralized) were coated in a small pan different amounts organic solution Eudragit® E leading thicknesses 150-400 urn. Drug from E-coated cores at 2.0-5.0 starts after 10-50 min due rapid dissolution film. At 6.8 lag times depend on composition and thickness film: In case carbomer-containing is induced by disruption film of...
informapharmascience.com参考文章(11)
Ronald M. Baecker, Jonathan Grudin, Saul Greenberg, William A. S. Buxton, Design and evaluation Human-Computer Interaction. pp. 73- 91 ,(1995)
Abraham Rubinstein, Boaz Tirosh, Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion Pharmaceutical Research. ,vol. 11, pp. 794- 799 ,(1994) , 10.1023/A:1018961204325
Jan Fallingborg, Lisbet Ambrosius Christensen, Bent Ascanius Jacobsen, Sten N�rby Rasmussen, Very low intraluminal colonic pH in patients with active ulcerative colitis Digestive Diseases and Sciences. ,vol. 38, pp. 1989- 1993 ,(1993) , 10.1007/BF01297074
W E Roediger, M J Lawson, V Kwok, A K Grant, P R Pannall, Colonic bicarbonate output as a test of disease activity in ulcerative colitis. Journal of Clinical Pathology. ,vol. 37, pp. 704- 707 ,(1984) , 10.1136/JCP.37.6.704
Takashi Ishibashi, Harumi Hatano, Masao Kobayashi, Masakazu Mizobe, Hiroyuki Yoshino, Design and evaluation of a new capsule-type dosage form for colon-targeted delivery of drugs International Journal of Pharmaceutics. ,vol. 168, pp. 31- 40 ,(1998) , 10.1016/S0378-5173(98)00082-9
D F Evans, G Pye, R Bramley, A G Clark, T J Dyson, J D Hardcastle, Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut. ,vol. 29, pp. 1035- 1041 ,(1988) , 10.1136/GUT.29.8.1035
Satoshi Ueda, Takehisa Hata, Sotoo Asakura, Hisami Yamaguchi, Masateru Kotani, Yoshio Ueda, Development of a novel drug release system, time-controlled explosion system (TES). I. Concept and design. Journal of Drug Targeting. ,vol. 2, pp. 35- 44 ,(1994) , 10.3109/10611869409015891
Hitoshi Kawai, Muneo Fukui, Shunsuke Watanabe, Masataka Katsuma, Colon-specific drug release system ,(1995)
Marianne Ashford, John T. Fell, David Attwood, Philip J. Woodhead, An in vivo investigation into the suitability of pH dependent polymers for colonic targeting International Journal of Pharmaceutics. ,vol. 91, pp. 193- 199 ,(1993) , 10.1016/0378-5173(93)90344-F
BENJAMIN J. RANKIN, EMANUEL D. SRIVASTAVA, CHRISTOPHER O. RECORD, JEFFEREY P. PEARSON, ADRIAN ALLEN, Patients with ulcerative colitis have reduced mucin polymer content in the adherent colonic mucus gel. Biochemical Society Transactions. ,vol. 23, ,(1995) , 10.1042/BST023104S