Growth hormone effects on hypertrophic scar formation: a randomized controlled trial of 62 burned children.

摘要: The hypercatabolism after massive pediatric burns has been effectively treated with recombinant human growth hormone, an anabolic agent that stimulates protein synthesis and abrogates arrest. While experimental studies have shown increased potential for fibrosis induced by hormone therapy, adverse effects on scars not investigated. Our aim was to evaluate hypertrophic scar formation in 62 patients randomized receive injections of 0.05 mg/kg/day or placebo, from discharge until 1 year burn. Scar scales were used scar-severity at discharge, 6, 9, 12, 18-24 months burn, three observers blinded treatment. Computer-assisted planimetry allowed quantification percentage formation. Types I III collagens localized quantified normal skin both groups, using immunohistochemistry confocal laser microscopy analysis. Insulin-like factor-1 blood levels helped assess compliance. Statistical analysis showed hypertrophy significantly 6 12 injury while decreasing postburn. statistically the reticular layer groups when compared paired skin. factor-treated group. No differences seen factor control scales, planimetry, immunohistochemistry. We concluded therapy did adversely affect should contraindicate administration as a therapeutic approach severely burned children.