A novel role for the Fc receptor gamma subunit: enhancement of Fc gamma R ligand affinity.

摘要: The Fc receptors (FcR), which belong to the immunoglobulin (Ig) superfamily, bind specific Ig isotypes with varying affinities triggering complex immune defense responses. Several of FcR that lack signaling motifs in their cytoplasmic domains rely on associated subunits transmit signals. Two classes portion IgG, gamma RI, and RIIIa associate a subunit shared among several FcR, chain, is involved receptor expression signal transduction. In this report, we propose novel role for chain enhance affinity R ligand. Our findings demonstrate RI requires -chain association attain high binding monomeric suggest intermediate isoform results from its chain. increase conferred by appears be mediated through transmembrane domain R, no requirement receptor.